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Giygas (foster son)
According to the beginning of Mother, she and George were abducted by aliens in the year 1906. George managed to escape two years later, but was unable to rescue Maria. As a result, she spent most of her life taking care of an infant Giegue, the game's primary villain.
She is a major driving force in the plot of Mother; the Eight Melodies is a lullaby that she sang to Giegue and the bulk of the plot revolves around learning said melody. It is later revealed that the character Queen Mary is the embodiment of Maria's consciousness and that Magicant is a mirage created from it. During the final battle, when using the check command, Maria's consciousness informs Ninten's party that the only thing that may defeat Giegue is to sing her lullaby with all of their heart.